Endothelial Function Test 

Disease Management Above the Standard

Assessing and Monitoring Your Vascular Health at Your Fingertips

The endothelium is the inner lining of the arterial wall that comes in direct contact with the blood. It is a physical barrier that prevents the penetration of circulating LDL cholesterol into the arterial wall. Without entry of LDL cholesterol into the arterial wall, plaques can't develop and grow. A healthy endothelial protects against atherosclerosis. It serves as a physical semipermeable barrier and secretes a substance called nitric oxide. Nitrite oxide causes the blood vessels to dilate in order to increase blood flow. Abnormal endothelial function causes a reduction in the secretion of nitric oxide. Lack of nitrite oxide causes the blood vessels to constrict instead. Normal endothelium function is essential in maintaining vascular health. Atherosclerosis and common cardiovascular risk factors such as high blood pressure, diabetes, high LDL cholesterol, smoking, unhealthy diet and overweight can cause abnormal endothelial function.

Atherosclerosis (plague build up) and risk factors impair the ability of the endothelium to secrete nitric oxide. Reduced availability of nitric oxide causes the blood vessels to become slow to dilate and slow to increase blood flow, even become constricted instead.  This response can be measured.  A healthy endothelium is the first defense against plaque build-up.


AFTER 1 year of healthier lifestyle: 10 lbs weight loss and regular exercise

You Tube Video: Endothelial function and testing explained.

© Rolando L. deGoma MD  2019     www.deGomaMD.com     Capital Cardiology Associates     Princeton Physicians' Organization